Evolution of neurotransmitter gamma-aminobutyric acid, glutamate and their receptors
نویسندگان
چکیده
منابع مشابه
Evolution of neurotransmitter gamma-aminobutyric acid, glutamate and their receptors.
Gamma-aminobutyric acid (GABA) and glutamate are two important amino acid neurotransmitters widely present in the nervous systems of mammals, insects, round worm, and platyhelminths, while their receptors are quite diversified across different animal phyla. However, the evolutionary mechanisms between the two conserved neurotransmitters and their diversified receptors remain elusive, and antago...
متن کاملEffect of Curcumin on the Hypothalamus Levels of the Potent Inhibitory Neurotransmitter ,Gamma aminobutyric acid
Background: There are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. According to several studies, elevated serum levels of gamma-amino butyric acid (GABA), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. The purpose of this research was to estimate the effects of curcumi...
متن کاملGAMMA-AMINOBUTYRIC ACID AND GLUTAMIC ACID IN HUNTINGTON'S DISEASE: INVESTIGATION OF NEUROTRANSMITTER RECEPTORS USING RADIOLABELED AGONISTS by-
3H-Muscimol, a structural analog of y-aminobutyric acid (GABA) , binds to rat brain synaptic membranes in a saturable manner, with a high affinity dissociation constant of 2.2 nM. Binding is increased in membranes that have been treated with Triton X-1Q0 and is not 3 dependent upon sodium. High affinity H-muscimol binding is regionally distributed, with highest binding density in the cerebellum...
متن کاملCyclothiazide potently inhibits gamma-aminobutyric acid type A receptors in addition to enhancing glutamate responses.
Ionotropic glutamate and gamma-aminobutyric acid type A (GABAA) receptors mediate critical excitatory and inhibitory actions in the brain. Cyclothiazide (CTZ) is well known for its effect of enhancing glutamatergic transmission and is widely used as a blocker for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor desensitization. Here, we report that in addi...
متن کاملgamma-Aminobutyric acid and benzodiazepine receptors: copurification and characterization.
gamma-Aminobutyric acid (GABA) and benzodiazepine receptors have been solubilized and purified by procedures such as gel filtration, ion-exchange, lectin, and affinity chromatographies. All of these procedures enhance the specific activity of each receptor to a similar extent. The drug specificities of [3H]muscimol and [3H]flunitrazepam binding sites are the same after extensive purification by...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Zoological Research
سال: 2013
ISSN: 0254-5853
DOI: 10.3724/sp.j.1141.2012.e05-06e75